Dr. Jerome H. Check, Dr. Rachel Cohen, and Dr. B. Katsoff have been doing research and have published many papers on this disorder. There are volumes of these papers and if you wish to have them sent to you, please email me at the address on my contact page of my blog. Here I will post excerpts of those papers for better understanding this
EXERPTS FROM VARIOUS RESEARCH PAPERS
"Another name that has recently been use for this condition causing edema is the leaky capillary syndrome. In contrast to dextroamphetamine sulfate, it can be a side effect of various medications affecting other biogenic amines. The edema may be associated with other symptomology, especially, but not limited to conditions associated with pain, eg., headaches, dysmenorrhea, or fibromyalgia. Besides edema and unexplained weight gain, there is a myriad of chronic refractory illnesses that show marked improvement following treatment with the sympathetic and amine dextroamphetamine sulfate."
"The best hypothesis to explain the impressive response to simpathomimetic amine therapy, is a high percentage of cases and that these disorders are linked by certain tissues, and have increased permeability allowing unwanted chemicals to permeate the tissue leading to inflammation and pain. This would be coupled in some instances with actual hypofunctioning of the sympathetic nervous system. The increased permeability may be genetic in nature or acquired, eg., from a traumatic event."
"Is thought to release dopamine from sympathetic nerve fibers. Dopamine is the main biogenic amine controlling cellular permeability."
"Other conditions not involving pain that have been refractory to standard therapy respond to sympathomimetic amine therapy, e.g., vasomotor symptoms, chronic fatigue, and you to uticaria. Not all of these conditions are associated with the edema. Gastrointestinal motility problems have also dramatically responded to sympathomimetic amines. Thus, some have referred to the condition as autonomic dystrophy." However, trauma by itself can lead to permeability defects without evidence of previous hypo functioning of the sympathetic nervous system. Thus, we have recently coined the term to encompass all these conditions as "the increased cellular permeability syndrome".
"George Thorne, in his initial investigation of the edema aspect of this condition, did find that it occurs in men, also but there was a 10:1 female/mail distribution. The present case demonstrates that not only can males develop the problem of edema, but it is a severe in males. The hypothesize mechanism of the edema is related to increased capillary permeability especially in the erect position where, related to an increase in hydrostatic pressure, possibly coupled by sympathetic nervous system function, fluid from the intra-vascular to the extra vascular space."
"Certain estrogen related events may exacerbate or precipitate the condition. This could explain why not all women with high serum estradiol levels and multiple follicles develop ovarian hyperstimulated syndrome when given human chorionic gonadotropin, i.e., it's worse in women who already have an intrinsic deficit in increased cellular permeability but below the level to get symptoms and signs without a precipitating event."
"The entire menstrual cycle but it can become worse premenstrual he. Isolated premenstrual edema has been thought to be related to relatively too much estrogen because of insufficient progesterone (P), but P supplementation does not produce great improvement. Edema restricted to the premenstrual time should also respond to sympathomimetic amine therapy(and is the author's unreported experience it is an effective treatment)."
**This site will keep publishing important information regarding this disorder. I just want to get this site online and I can continue to work on providing more information.